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This household contains only one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, in addition to histone, a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and elements of the TATA binding protein (TBP) complicated, TBP-related elements TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-K (target lysine is bold), can also be acknowledged by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of these substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a traditional model for dynamic lysine methylation of each histone and non-histone proteins.

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